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Bibliography can be found below or at this URL: https://www.ncbi.nlm.nih.gov/myncbi/roberta.marongiu.1/bibliography/public/
Marongiu R, Wang J, Unda SR, Barbera J, Velazquez L, Li R, Jimenez-Gonzalez M, Tower W, de Silva N, Retik R, Stanley SA, Kaplitt MG. Control of feeding behavior by modified retrograde AAV to the gastrointestinal tract nerve afferents. Sci Rep. 2025 Dec 14;16(1):1773. doi: 10.1038/s41598-025-31377-4. PubMed PMID: 41392163; PubMed Central PMCID: PMC12804985.
Leri M, Bertolini A, Diaz M, Marongiu R. Editorial: Estrogens and neurodegeneration: a link between menopause and Alzheimer's disease in women. Front Mol Biosci. 2025;12:1727385. doi: 10.3389/fmolb.2025.1727385. eCollection 2025. PubMed PMID: 41280324; PubMed Central PMCID: PMC12635531.
Dautan D, Camargo A, Branzell N, Brioschi VI, Doyon D, Covatta E, Marongiu R, Kaplitt M, Chergui K, Zhang X, Svenningsson P. Altered acetylcholine modulations and corticoaccumbal pathway in P11-linked social dysfunction. Mol Psychiatry. 2025 Nov 3;. doi: 10.1038/s41380-025-03324-2. [Epub ahead of print] PubMed PMID: 41184570.
Gregory S, Bridgeman K, Darwin H, Barbato M, Booi L, Serrat AB, Chadha AS, Farina FR, Jenkins N, Jutila OI, Low A, Marongiu R, Naci L, Pulford P, Ritchie CW, Ritchie K, Udeh-Momoh C, Watermeyer T, Welstead M, Muniz-Terrera G. Associations of estrogen with modifiable and non-modifiable risk factors for dementia: A narrative review. Alzheimers Dement. 2025 Nov;21(11):e70873. doi: 10.1002/alz.70873. Review. PubMed PMID: 41263327; PubMed Central PMCID: PMC12631545.
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Trigiani L, Chernavsky N, Kim R, Hong N, Hawkins R, Le E, Bahninameh Z, Yamaguchi K, Bernard J, Huang A, Rivera D, Allan-Rahill N, Lamont M, Marongiu R, Iadecola C, Nishimura N, Schaffer C. Memory deficits in hypertensive ApoE4 mice reversed by P2Y12 inhibition via different mechanisms in males and perimenopausal females. Res Sq. 2025 Sep 26;. doi: 10.21203/rs.3.rs-7643285/v1. PubMed PMID: 41041548; PubMed Central PMCID: PMC12486115.
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Mostert CM, Udeh-Momoh C, Winkler AS, McLaughlin C, Eyre H, Salama M, Ranchod K, Trepel D, Vradenburg G, Hynes W, Fieggen G, Ali S, Mekkaoui NEL, Landay A, Bobrow K, Muyela L, Atkins K, Chadha AS, Marongiu R, Barbato M, Nightingale S, Joska J, Njamnshi AK, Rizig M, Kahn JG, Blackmon K, Merali Z, Ibanez A. Broadening dementia risk models: building on the 2024 Lancet Commission report for a more inclusive global framework. EBioMedicine. 2025 Oct;120:105950. doi: 10.1016/j.ebiom.2025.105950. Epub 2025 Sep 25. Review. PubMed PMID: 41004922; PubMed Central PMCID: PMC12509747.
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Barbato M, Guzman B, Dixit S, Chadha AS, Marongiu R. A sex- and gender-informed future for Parkinson's disease care. Clin Transl Med. 2025 Jun;15(6):e70382. doi: 10.1002/ctm2.70382. PubMed PMID: 40551585; PubMed Central PMCID: PMC12185897.
Marongiu R, Platholi J, Park L, Yu F, Sommer G, Woods C, Milner TA, Glass MJ. Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer's disease. Front Mol Biosci. 2025;12:1597130. doi: 10.3389/fmolb.2025.1597130. eCollection 2025. PubMed PMID: 40438709; PubMed Central PMCID: PMC12116374.
Antoniazzi AM, Unda SR, Norman S, Pomeranz LE, Marongiu R, Stanley SA, Friedman JM, Kaplitt MG. Non-invasive in vivo bidirectional magnetogenetic modulation of pain circuits. bioRxiv. 2025 Mar 19;. doi: 10.1101/2025.03.18.644041. PubMed PMID: 40166248; PubMed Central PMCID: PMC11957015.
Wichmann T, Nelson A, Torres ERS, Svenningsson P, Marongiu R. Leveraging animal models to understand non-motor symptoms of Parkinson's disease. Neurobiol Dis. 2025 May;208:106848. doi: 10.1016/j.nbd.2025.106848. Epub 2025 Feb 27. Review. PubMed PMID: 40023327.
Castro-Aldrete L, Huc M, Domingos J, Vaudano E, Klietz M, Trenkwalder C, Oosterbaan A, Flanagan R, Marongiu R, Santuccione-Chadha A. Using a sex- and gender-informed lens to enhance care in Parkinson's disease. Nat Med. 2025 Feb;31(2):367-369. doi: 10.1038/s41591-024-03363-2. PubMed PMID: 39753966.
Moreno-Gonzalez I, Garcia-Martin J, Marongiu R. Editorial: Animal models of Alzheimer's disease and other dementias: past, present, and future. Front Aging Neurosci. 2024;16:1539837. doi: 10.3389/fnagi.2024.1539837. eCollection 2024. PubMed PMID: 39834617; PubMed Central PMCID: PMC11743453.
Unda SR, Pomeranz LE, Marongiu R, Yu X, Kelly L, Hassanzadeh G, Molina H, Vaisey G, Wang P, Dyke JP, Fung EK, Grosenick L, Zirkel R, Antoniazzi AM, Norman S, Liston CM, Schaffer C, Nishimura N, Stanley SA, Friedman JM, Kaplitt MG. Bidirectional regulation of motor circuits using magnetogenetic gene therapy. Sci Adv. 2024 Oct 11;10(41):eadp9150. doi: 10.1126/sciadv.adp9150. Epub 2024 Oct 9. PubMed PMID: 39383230; PubMed Central PMCID: PMC11463271.
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Dautan D, Paslawski W, Montejo SG, Doyon DC, Marangiu R, Kaplitt MG, Chen R, Dawson VL, Zhang X, Dawson TM, Svenningsson P. Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson's Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior Disorder. bioRxiv. 2024 Apr 26;. doi: 10.1101/2024.04.22.590542. PubMed PMID: 38712208; PubMed Central PMCID: PMC11071367.
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Platholi J, Marongiu R, Park L, Yu F, Sommer G, Weinberger R, Tower W, Milner TA, Glass MJ. Hippocampal glial inflammatory markers are differentially altered in a novel mouse model of perimenopausal cerebral amyloid angiopathy. Front Aging Neurosci. 2023;15:1280218. doi: 10.3389/fnagi.2023.1280218. eCollection 2023. PubMed PMID: 38035277; PubMed Central PMCID: PMC10684955.
Unda SR, Marciano S, Milner TA, Marongiu R. State-of-the-art review of the clinical research on menopause and hormone replacement therapy association with Parkinson's disease: What meta-analysis studies cannot tell us. Front Aging Neurosci. 2022;14:971007. doi: 10.3389/fnagi.2022.971007. eCollection 2022. Review. PubMed PMID: 36337706; PubMed Central PMCID: PMC9631815.
Milner TA, Chen RX, Welington D, Rubin BR, Contoreggi NH, Johnson MA, Mazid S, Marques-Lopes J, Marongiu R, Glass MJ. Angiotensin II differentially affects hippocampal glial inflammatory markers in young adult male and female mice. Learn Mem. 2022 Sep;29(9):265-273. doi: 10.1101/lm.053507.121. Print 2022 Sep. PubMed PMID: 36206386; PubMed Central PMCID: PMC9488028.
Jimenez-Gonzalez M, Li R, Pomeranz LE, Alvarsson A, Marongiu R, Hampton RF, Kaplitt MG, Vasavada RC, Schwartz GJ, Stanley SA. Mapping and targeted viral activation of pancreatic nerves in mice reveal their roles in the regulation of glucose metabolism. Nat Biomed Eng. 2022 Nov;6(11):1298-1316. doi: 10.1038/s41551-022-00909-y. Epub 2022 Jul 14. PubMed PMID: 35835995; PubMed Central PMCID: PMC9669304.
Unda SR, Antoniazzi AM, Altschul DJ, Marongiu R. Peripheral Leukocytosis Predicts Cognitive Decline but Not Behavioral Disturbances: A Nationwide Study of Alzheimer's and Parkinson's Disease Patients. Dement Geriatr Cogn Disord. 2021;50(2):143-152. doi: 10.1159/000516340. Epub 2021 May 31. PubMed PMID: 34058741; PubMed Central PMCID: PMC8376803.
Marongiu R. Accelerated Ovarian Failure as a Unique Model to Study Peri-Menopause Influence on Alzheimer's Disease. Front Aging Neurosci. 2019;11:242. doi: 10.3389/fnagi.2019.00242. eCollection 2019. PubMed PMID: 31551757; PubMed Central PMCID: PMC6743419.
Marongiu R. Leucine-Rich Repeat Kinase 2 regulates Parkinson’s disease levodopa-induced dyskinesia. Journal of Parkinson's Disease. World Parkinson's Disease Congress; 2019; United States. IOS Press; c2019.
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A Clinical Precision Medicine Approach Reduces Alzheimer’s, Dementia and Vascular Risk and Improves Cognition: A Prospective Cohort Study. Neurology; ; US. c2017.
Kelm-Nelson CA, Brauer AFL, Barth KJ, Lake JM, Sinnen MLK, Stehula FJ, Muslu C, Marongiu R, Kaplitt MG, Ciucci MR. Characterization of early-onset motor deficits in the Pink1-/- mouse model of Parkinson disease. Brain Res. 2018 Feb 1;1680:1-12. doi: 10.1016/j.brainres.2017.12.002. Epub 2017 Dec 8. PubMed PMID: 29229503; PubMed Central PMCID: PMC5767140.
Schintu N, Zhang X, Alvarsson A, Marongiu R, Kaplitt MG, Greengard P, Svenningsson P. p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1429-34. doi: 10.1073/pnas.1524303113. Epub 2016 Jan 19. PubMed PMID: 26787846; PubMed Central PMCID: PMC4747690.
Marongiu R, Arango-Lievano M, Francardo V, Morgenstern P, Zhang X, Cenci MA, Svenningsson P, Greengard P, Kaplitt MG. Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1423-8. doi: 10.1073/pnas.1524387113. Epub 2016 Jan 19. PubMed PMID: 26787858; PubMed Central PMCID: PMC4747714.
Gürsel DB, Banu MA, Berry N, Marongiu R, Burkhardt JK, Kobylarz K, Kaplitt MG, Rafii S, Boockvar JA. Tight regulation between cell survival and programmed cell death in GBM stem-like cells by EGFR/GSK3b/PP2A signaling. J Neurooncol. 2015 Jan;121(1):19-29. doi: 10.1007/s11060-014-1602-3. Epub 2014 Oct 26. PubMed PMID: 25344882.
Arango-Lievano M, Schwarz JT, Vernov M, Wilkinson MB, Bradbury K, Feliz A, Marongiu R, Gelfand Y, Warner-Schmidt J, Nestler EJ, Greengard P, Russo SJ, Kaplitt MG. Cell-type specific expression of p11 controls cocaine reward. Biol Psychiatry. 2014 Nov 15;76(10):794-801. doi: 10.1016/j.biopsych.2014.02.012. Epub 2014 Feb 26. PubMed PMID: 24725970; PubMed Central PMCID: PMC4145045.
Lenzi P, Marongiu R, Falleni A, Valente EM, Ricciardi MP, Ruggieri S, Frati L, Paparelli A. Genetic modulation of PINK1 differentially affects mitophagy compared with autophagy disclosing common mechanisms of genetic and environmental parkinsonism. Italian Journal of Anatomy and Embriology. 2012; 117(2):97.
Lenzi P, Marongiu R, Falleni A, Gelmetti V, Busceti CL, Michiorri S, Valente EM, Fornai F. A subcellular analysis of genetic modulation of PINK1 on mitochondrial alterations, autophagy and cell death. Arch Ital Biol. 2012 Jun-Sep;150(2-3):194-217. doi: 10.4449/aib.v150i2/3.1417. PubMed PMID: 23165879.
Morgenstern PF, Marongiu R, Musatov SA, Kaplitt MG. Adeno-associated viral gene delivery in neurodegenerative disease. Methods Mol Biol. 2011;793:443-55. doi: 10.1007/978-1-61779-328-8_29. PubMed PMID: 21913118.
Michiorri S, Gelmetti V, Giarda E, Lombardi F, Romano F, Marongiu R, Nerini-Molteni S, Sale P, Vago R, Arena G, Torosantucci L, Cassina L, Russo MA, Dallapiccola B, Valente EM, Casari G. The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy. Cell Death Differ. 2010 Jun;17(6):962-74. doi: 10.1038/cdd.2009.200. Epub 2010 Jan 8. PubMed PMID: 20057503.
Marongiu R, Spencer B, Crews L, Adame A, Patrick C, Trejo M, Dallapiccola B, Valente EM, Masliah E. Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux. J Neurochem. 2009 Mar;108(6):1561-74. doi: 10.1111/j.1471-4159.2009.05932.x. Epub 2009 Jan 24. PubMed PMID: 19166511; PubMed Central PMCID: PMC3902824.
Marongiu R, Ferraris A, Ialongo T, Michiorri S, Soleti F, Ferrari F, Elia AE, Ghezzi D, Albanese A, Altavista MC, Antonini A, Barone P, Brusa L, Cortelli P, Martinelli P, Pellecchia MT, Pezzoli G, Scaglione C, Stanzione P, Tinazzi M, Zecchinelli A, Zeviani M, Cassetta E, Garavaglia B, Dallapiccola B, Bentivoglio AR, Valente EM. PINK1 heterozygous rare variants: prevalence, significance and phenotypic spectrum. Hum Mutat. 2008 Apr;29(4):565. doi: 10.1002/humu.20719. PubMed PMID: 18330912.
Marongiu R, Brancati F, Antonini A, Ialongo T, Ceccarini C, Scarciolla O, Capalbo A, Benti R, Pezzoli G, Dallapiccola B, Goldwurm S, Valente EM. Whole gene deletion and splicing mutations expand the PINK1 genotypic spectrum. Hum Mutat. 2007 Jan;28(1):98. doi: 10.1002/humu.9472. PubMed PMID: 17154281.
Marongiu R, Ghezzi D, Ialongo T, Soleti F, Elia A, Cavone S, Albanese A, Altavista MC, Barone P, Brusa L, Cortelli P, Petrozzi L, Scaglione C, Stanzione P, Tinazzi M, Zeviani M, Dallapiccola B, Bentivoglio AR, Valente EM, Garavaglia B. Frequency and phenotypes of LRRK2 G2019S mutation in Italian patients with Parkinson's disease. Mov Disord. 2006 Aug;21(8):1232-5. doi: 10.1002/mds.20890. PubMed PMID: 16622859.
Criscuolo C, Volpe G, De Rosa A, Varrone A, Marongiu R, Mancini P, Salvatore E, Dallapiccola B, Filla A, Valente EM, De Michele G. PINK1 homozygous W437X mutation in a patient with apparent dominant transmission of parkinsonism. Mov Disord. 2006 Aug;21(8):1265-7. doi: 10.1002/mds.20933. PubMed PMID: 16700027.
Valente EM, Salvi S, Ialongo T, Marongiu R, Elia AE, Caputo V, Romito L, Albanese A, Dallapiccola B, Bentivoglio AR. PINK1 mutations are associated with sporadic early-onset parkinsonism. Ann Neurol. 2004 Sep;56(3):336-41. doi: 10.1002/ana.20256. PubMed PMID: 15349860.